Will & Grace (1998 - 2006)
Snappy hit about a straight woman and a gay man who are best friends. She's a decorator with a snippy, self-absorbed assistant; he's a lawyer with a flamboyant buddy who has trouble holding a job. The scripts are laced with pop-culture references and in-jokes, but what's best about this sitcom is the cast chemistry. What doesn't always work so well is the too-frequent big-name guests, who have included Michael Douglas, Cher, Madonna and Matt Damon.
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