Stan Lee Creator Steve Ditko Creator Hudson Thames Peter Parker, Spider-Man Voice Eugene Byrd Lonnie Lincoln Voice Grace Song Nico Minoru Voice Hugh Dancy Otto Octavius, Doctor Octopus Voice Kari Wahlgren May ParkerZeno Robinson:Harry Osborn Voice Jonathan Medina Mac Gargan Voice Cathy Ang Pearl Pangan Voice Colman Domingo Norman Osborn Voice Robin Atkin Downes Doctor Strange Guest Voice Erica Luttrell Asha Guest Voice Aleks Le Amadeus Cho Guest Voice Leilani Barrett Big Donovan Guest Voice Big E Bulldozer Guest Voice Zeno Robinson Harry Osborn Voice Louis D'Esposito Executive Producer Kevin Feige Executive Producer Jeff Trammell Executive Producer, Writer Brad Winderbaum Executive Producer Dana Vasquez-Eberhardt Executive Producer Melchior Zwyer Director Charlie Neuner Writer Stu Livingston Director Liza Singer Director Raven Koné Writer