Osmosis Jones

Critics Consensus

The animated portion of Osmosis is zippy and fun, but the live-action portion is lethargic.

55%

TOMATOMETER

Total Count: 108
User image

Osmosis Jones Photos

Movie Info

Peter Farrelly and Bobby Farrelly, the impish impresarios of gross-out comedy, take their body function-inspired humor to new extremes in this mixture of live action and animation. Bill Murray stars as Frank, a zoo worker suffering from the effects of an unknown malady he contracted after eating an egg contaminated with simian saliva. Unknown to Frank, the inside of his body is actually a city (the City of Frank) teeming with cellular life, where the mysterious illness he's fighting is an invading enemy that must be defeated at all costs. It's up to Osmosis Jones (voice of Chris Rock), a white blood cell cop, and Drix (voice of David Hyde Pierce), a rookie over-the-counter medication, to hunt down and stop a lethal virus (Laurence Fishburne) who's got an inferiority complex. Along the way, the partners visit Frank's runny nostrils (Booger Dam) and a bar called, appropriately enough, the Zit. Osmosis Jones costars Molly Shannon and Chris Elliott, and features the vocal talents of William Shatner, producer Joel Silver, and singer Brandy Norwood. ~ Karl Williams, Rovi

Watch it now

Cast

Bill Murray
as Frank Detorri
Chris Rock
as Osmosis Jones
William Shatner
as Mayor Phlegmming
Molly Shannon
as Mrs. Boyd
Elena Franklin
as Shane Detorri
Kid Rock
as Kidney Rock
Ron Howard
as Tom Colonic
Dan Murphy
as Zookeeper Superintendent
The O'Day Family
as Zoo Visitors & Staff
Maura O'Brien
as Emergency Room Nurse
Marlene Malone
as Zoo Visitors & Staff
Barbara O'Connor
as Zoo Visitors & Staff
Grady O'Connor
as Zoo Visitors & Staff
The Oberholtzer Family
as Science Fair Family
Emily O'Donnell
as Science Fair Contestant
Emily O'Day
as Volcano Gal
Colleen O'Donnell
as Docky's Clamshack
Diana O'Donnell
as Science Fair Contestant
The Madigan Family
as Science Fair Family
Bruce McIntyre
as Pea Soup Staff
Ruth Meyer
as Zoo Visitors & Staff
The Mone Family
as Docky's Clamshack
Brian Mone
as Police Officer
Bob O'Brien
as Zoo Visitors & Staff
Mandy Marsh
as Zoo Visitors & Staff
Jillian Nicewicz
as Docky's Clamshack
Jo Ann Ninewicz
as Docky's Clamshack
The Murphy Family
as Zoo Visitors & Staff
Joe Murphy
as Bikini Gang
The Neville Family
as Zoo Visitors & Staff
Jack McCullough
as Zookeeper
The Urann Family
as Science Fair Family
The Sumner Family
as Science Fair Family
The Tom Beauchene Family
as Zoo Visitors & Staff
The Sullivan Family
as Zoo Visitors & Staff
Morgan Wentzell
as Zoo Visitors & Staff
Jacqueline Wentzell
as Zoo Visitors & Staff
The Winans Family
as Science Fair Family
The Vuilleumier Family
as Science Fair Family
Kathy Wege
as Volcano Lady
Bill Wade
as Pea Soup Staff
Warwick West Side All-Stars
as Zoo Visitors & Staff
Mattie Ostiguy
as Emergency Room Nurse
Jesse Peter
as Laughing Boy
The Perry Family
as Zoo Visitors & Staff
The Peterson Family
as Science Fair Family
Zak Penn
as Emergency Room Doctor #3
The Pelham Family
as Zoo Visitors & Staff
Amy Suhay
as Bikini Gang
Dick Silva
as Science Fair Contestant
The Shields Family
as Zoo Visitors & Staff
The Reske Family
as Zoo Visitors & Staff
The Ripley Family
as Science Fair Family
Dick Rubin
as Bikini Gang
The Roy Family
as Zoo Visitors & Staff
The Woodgate Family
as Zoo Visitors & Staff
Bo Cleary
as Pea Soup Staff
Diane Conrad
as Zoo Visitors & Staff
Judy Conrad
as Zoo Visitors & Staff
Brianna Cabral
as Volcano Gal
The Charpentier Family
as Docky's Clamshack
The Cavallo Family
as Science Fair Family
Nancy Byers
as Pea Soup Supervisor
Buzz Dunn
as Science Fair Contestant
Laura Dunn
as Science Fair Contestant
Silk Willy Dunn
as Oyster Boy
Jimmy Heres
as Zoo Visitors & Staff
Ben Stein
as The Doctor
Jamie Heres
as Zoo Visitors & Staff
Joel Silver
as The Chief
Helen Britten
as Zoo Visitors & Staff
The Dunphy Family
as Zoo Visitors & Staff
Tom Barbieri
as Zoo Visitors & Staff
Kathryn Frick
as Nurse #1
Thomas Jordan
as Zoo Visitors & Staff
John-Eliot Jordan
as Pea Soup Manager
The Krupa Family
as Docky's Clamshack
John Britten
as Zoo Visitors & Staff
Grace Costa
as Emergency Room Nurse
The Hallowell Family
as Zoo Visitors & Staff
Kevin Flynn
as Docky's Clamshack Waiter
Catherine Dunphy
as Volcano Gal
Christina Kacmar
as Science Fair Contestant
Erica Johnson
as Zoo Visitors & Staff
Kelsey Jordan
as Bus Girl #1
Nicole Brathwaite
as Volcano Gal
The Coughlan Family
as Science Fair Family
Patricia Guiggey
as Bikini Gang
Zen Gesner
as Emergency Room Doctor #1
Sidney Bartholomew Jr.
as Zoo Visitors & Staff
The Bill Beauchene Family
as Science Fair Family
Rachael Kasner
as Bikini Gang
Kena Flynn
as Science Fair Contestant
George Kouri
as Bikini Gang
The Brumley Family
as Science Fair Family
The Curran Family
as Zoo Visitors & Staff
Anna Byers
as Bus Girl #2
Bob Fennessey
as Zoo Visitors & Staff
Jackie Flynn
as School Janitor
The Buechs Family
as Science Fair Family
The Kouri Family
as Zoo Visitors & Staff
Heidi Hetzel
as Bikini Gang
Maryjane Foy
as Docky's Clamshack
Allison Barbieri
as Zoo Visitors & Staff
The Brown Family
as Zoo Visitors & Staff
Krista-Jean Froand
as Science Fair Contestant
Sean Fitzgerald
as Police Officer
Allison Kacmar
as Science Fair Contestant
The Ferguson Family
as Zoo Visitors & Staff
Sean Gildea
as Dreamy Photographer
View All

Critic Reviews for Osmosis Jones

All Critics (108) | Top Critics (33)

Osmosis Jones Quotes

News & Features