Osmosis Jones

2001

Osmosis Jones

Critics Consensus

The animated portion of Osmosis is zippy and fun, but the live-action portion is lethargic.

55%

TOMATOMETER

Total Count: 108

41%

Audience Score

User Ratings: 62,663
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Osmosis Jones Photos

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Movie Info

Peter Farrelly and Bobby Farrelly, the impish impresarios of gross-out comedy, take their body function-inspired humor to new extremes in this mixture of live action and animation. Bill Murray stars as Frank, a zoo worker suffering from the effects of an unknown malady he contracted after eating an egg contaminated with simian saliva. Unknown to Frank, the inside of his body is actually a city (the City of Frank) teeming with cellular life, where the mysterious illness he's fighting is an invading enemy that must be defeated at all costs. It's up to Osmosis Jones (voice of Chris Rock), a white blood cell cop, and Drix (voice of David Hyde Pierce), a rookie over-the-counter medication, to hunt down and stop a lethal virus (Laurence Fishburne) who's got an inferiority complex. Along the way, the partners visit Frank's runny nostrils (Booger Dam) and a bar called, appropriately enough, the Zit. Osmosis Jones costars Molly Shannon and Chris Elliott, and features the vocal talents of William Shatner, producer Joel Silver, and singer Brandy Norwood. ~ Karl Williams, Rovi

Cast

Bill Murray
as Frank Detorri
Chris Rock
as Osmosis Jones
Laurence Fishburne
as Thrax
David Hyde Pierce
as Drix
William Shatner
as Mayor Phlegmming
Molly Shannon
as Mrs. Boyd
Chris Elliott
as Bob
Elena Franklin
as Shane Detorri
Kid Rock
as Kidney Rock
Ron Howard
as Tom Colonic
Brandy Norwood
as Leah
Dan Murphy
as Zookeeper Superintendent
Joe C
The O'Day Family
as Zoo Visitors & Staff
Maura O'Brien
as Emergency Room Nurse
Marlene Malone
as Zoo Visitors & Staff
Barbara O'Connor
as Zoo Visitors & Staff
Grady O'Connor
as Zoo Visitors & Staff
Danny Mann
The Oberholtzer Family
as Science Fair Family
Emily O'Donnell
as Science Fair Contestant
Ken Olson
Emily O'Day
as Volcano Gal
Colleen O'Donnell
as Docky's Clamshack
Diana O'Donnell
as Science Fair Contestant
The Madigan Family
as Science Fair Family
Sherry Lynn
Bruce McIntyre
as Pea Soup Staff
Ruth Meyer
as Zoo Visitors & Staff
The Mone Family
as Docky's Clamshack
Brian Mone
as Police Officer
Stuttering John Melendez
Mickie T. McGowan
Hector Mercado
Bob O'Brien
as Zoo Visitors & Staff
Mandy Marsh
as Zoo Visitors & Staff
Jillian Nicewicz
as Docky's Clamshack
Jo Ann Ninewicz
as Docky's Clamshack
The Murphy Family
as Zoo Visitors & Staff
Joe Murphy
as Bikini Gang
The Neville Family
as Zoo Visitors & Staff
Jack McCullough
as Zookeeper
Anne Lockhart
Nikki Tyler-Flynn
as Nurse #2
Paul Tuerpé
Uncle Kracker
The Urann Family
as Science Fair Family
The Sumner Family
as Science Fair Family
Keri Tombazian
Steve Susskind
The Tom Beauchene Family
as Zoo Visitors & Staff
The Sullivan Family
as Zoo Visitors & Staff
Morgan Wentzell
as Zoo Visitors & Staff
Jacqueline Wentzell
as Zoo Visitors & Staff
The Winans Family
as Science Fair Family
Robert Wisdom
Chandler Vuillemier
as Volcano Gal
The Vuilleumier Family
as Science Fair Family
Kathy Wege
as Volcano Lady
Bill Wade
as Pea Soup Staff
Warwick West Side All-Stars
as Zoo Visitors & Staff
Mattie Ostiguy
as Emergency Room Nurse
Jesse Peter
as Laughing Boy
The Perry Family
as Zoo Visitors & Staff
The Peterson Family
as Science Fair Family
Chris Phillips
Lynne Redding
Paul Pape
Zak Penn
as Emergency Room Doctor #3
Marilyn Pasekoff
The Pelham Family
as Zoo Visitors & Staff
Amy Suhay
as Bikini Gang
Dick Silva
as Science Fair Contestant
The Shields Family
as Zoo Visitors & Staff
Herschel Sparber
Doug Stone
The Reske Family
as Zoo Visitors & Staff
The Ripley Family
as Science Fair Family
Dick Rubin
as Bikini Gang
Al Rodrigo
The Roy Family
as Zoo Visitors & Staff
The Woodgate Family
as Zoo Visitors & Staff
Bo Cleary
as Pea Soup Staff
Paul Christie
Diane Conrad
as Zoo Visitors & Staff
Judy Conrad
as Zoo Visitors & Staff
Brianna Cabral
as Volcano Gal
The Charpentier Family
as Docky's Clamshack
Michael Carven
The Cavallo Family
as Science Fair Family
Nancy Byers
as Pea Soup Supervisor
Buzz Dunn
as Science Fair Contestant
The Artist Formerly Known As Docky
as Bikini Gang
Laura Dunn
as Science Fair Contestant
Silk Willy Dunn
as Oyster Boy
Marc Hyman
as Emergency Room Doctor #2
Kathryn Frick
as Nurse #1
Janis Dardaris
Thomas Jordan
as Zoo Visitors & Staff
Joel Silver
as The Chief
Elizabeth Jordan
as Nurse #3
John Britten
as Zoo Visitors & Staff
Eddie Barth
The Krupa Family
as Docky's Clamshack
Donald Fullilove
Grace Costa
as Emergency Room Nurse
The Hallowell Family
as Zoo Visitors & Staff
Art Kimbro
Rodger Bumpass
Kevin Flynn
as Docky's Clamshack Waiter
Zen Gesner
as Emergency Room Doctor #1
Catherine Dunphy
as Volcano Gal
Ben Stein
as The Doctor
Christina Kacmar
as Science Fair Contestant
Erica Johnson
as Zoo Visitors & Staff
Kelsey Jordan
as Bus Girl #1
Nicole Brathwaite
as Volcano Gal
Jason Krause
The Coughlan Family
as Science Fair Family
Eddie Frierson
Patricia Guiggey
as Bikini Gang
Steve Berens
as Stunts
Sidney Bartholomew Jr.
as Zoo Visitors & Staff
The Bill Beauchene Family
as Science Fair Family
Stefanie Eulinberg
Carlos Alazraqui
Rachael Kasner
as Bikini Gang
Jonathan Adams
Kena Flynn
as Science Fair Contestant
Rif Hutton
The Brumley Family
as Science Fair Family
George Kouri
as Bikini Gang
Keith Anthony Lubow-Bellamy
The Curran Family
as Zoo Visitors & Staff
Jackie Gonneau
Anna Byers
as Bus Girl #2
Jackie Flynn
as School Janitor
The Buechs Family
as Science Fair Family
Bob Fennessey
as Zoo Visitors & Staff
The Kouri Family
as Zoo Visitors & Staff
Heidi Hetzel
as Bikini Gang
Allison Barbieri
as Zoo Visitors & Staff
Maryjane Foy
as Docky's Clamshack
The Brown Family
as Zoo Visitors & Staff
Richard Steven Horvitz
Wendy Dillon
Krista-Jean Froand
as Science Fair Contestant
Allison Kacmar
as Science Fair Contestant
Sean Fitzgerald
as Police Officer
Sean Gildea
as Dreamy Photographer
Jimmie Bones
John-Eliot Jordan
as Pea Soup Manager
The Ferguson Family
as Zoo Visitors & Staff
Antonio Fargas
Jimmy Heres
as Zoo Visitors & Staff
Jamie Heres
as Zoo Visitors & Staff
Joyce Kurtz
Shannon Gregory
Helen Britten
as Zoo Visitors & Staff
Sally Ann Brooks
Tom Barbieri
as Zoo Visitors & Staff
The Dunphy Family
as Zoo Visitors & Staff
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Critic Reviews for Osmosis Jones

All Critics (108) | Top Critics (33) | Fresh (59) | Rotten (49)

View All Critic Reviews (108)

Audience Reviews for Osmosis Jones

  • Apr 16, 2012
    A fun live action comedy that will not only appeal to children but also the humour will be funny to adults. With a new and unique concept Osmosis Jones offered the audience a different experience in animation and will capture the viewer with the hilarious Bill Murray and Chris Rock taking the lead roles. It was at times funny, violent, entertaining, sad and all the time captivating. The Farrelly Brothers bring all their experience into something different to their style and it works really well. Overall this is a fun and entertaining child's live action that is for all audiences some jokes for children, others for adults; it has a really working formula to it that always keeps the viewer satisfied.
    Luke C Super Reviewer
  • Dec 03, 2011
    Osmosis: Yo! You see this badge? You see this gun? You see this gooey, white saccus membranous 'round my personhood?... Well, you dealin' with a white blood cell here! I should be out in the veins, fighting disease, not in the mouth on tartar control.  "He's one cell of a guy." Osmosis Jones is a a clever and unique film from the Farrelly brothers. I still don't really like it though. Yeah, the premise is really cool, but the overall execution of that premise is not. The movie turns into a one joke comedy after the initial awesomeness of the first 20 minutes or so. It didn't seem like the Farrelly's knew how to keep this story flowing and the audience caring. They let an extremely smart and cool idea go wasted because of their need to incorporate as many bodily function, fungus and zit jokes as they could into a an hour and a half running time.  Osmosis is a white blood cell in the body of Frank. Frank is an unhealthy, overweight zookeeper, who is raising his young daughter all by himself after his wife has passed away. The movie follows two story lines. There's the live action storyline with the family dynamics of the father-daughter relationship. Then there's an animated storyline going on inside Frank's body. A virus has just come into his body with the intentions of killing Frank. It's up to Osmosis to take the virus down. He also has to fight all the normal problems that affect cops in cop dramas, such as a mistake a long time ago and a boss that doesn't really believe in him. I like the initial setup for this movie, but it just never gets where it needs to be. The film has a pretty incredible cast. Bill Murray plays Frank, and although it isn't one of his more memorable roles, it's still Bill Murray. Then there's the voice cast with people like Chris Rock, Laurence Fishburne, William Shatner and David Hyde Pierce. All the voice actors really sell their performances and sound perfect for their particular character. This is most notable with Fishburne's role as Thrax, the killer virus. He gives a great voice performance and is perfect for the role. Along with the great cast and the cool premise the movie has some great references throughout. At the end, there are some great uses of Titanic's final scenes. Then there's a band that plays at one point in the movie called Kidney Rock, that has Kid Rock and Joe C singing for it. All these elements should add up to something great and the disappointing part of it is that it doesn't. The film had potential, but it still ended up being a misfire for the Farrelly brothers.
    Melvin W Super Reviewer
  • Dec 02, 2011
    Clever, funny, a little too gross, but still is a pretty good animated film, not Bill Murrays funniest role though.
    Bradley W Super Reviewer
  • Oct 09, 2011
    Clever, funny, a little too gross, but still is a pretty good animated film, not Bill Murrays funniest role though.
    Jim C Super Reviewer
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