Rupert Wainwright Director Patricia Arquette Frankie Paige Actor Gabriel Byrne Father Andrew Kiernan Actor Jonathan Pryce Cardinal Daniel Houseman Actor Nia Long Donna Chadway Actor Thomas Kopache Father Durning Actor Rade Serbedzija Marion Petrocelli Actor Enrico Colantoni Father Dario Actor Dick Latessa Father Gianni Delmonico Actor Portia de Rossi Jennifer Kelliho Actor Patrick Muldoon Steven Actor Ann Cusack Dr. Reston Actor Shaun Toub Doctor Actor Tom Hodges E.R. Nurse Actor Lydia Hazan Attending Nurse Actor Shaun Duke Moosekian Dr. Eckworth Actor Valarie Trapp Woman with a Baby Actor Kessia Kordelle Cheryl Actor Frankie Thorn Donna's Customer Actor Mariah Nunn Sister Angela Actor Tom Fahn MTA Man Actor Marilyn Pitzer Homeless Woman Actor Jack Donner Father Alameida Actor Richard Conti Valet Priest Actor Mary Linda Phillips Sister Agnes Actor Liz Cruz Waitress Actor Faith Christopher Waitress Actor Joe Ruffo Guard Actor Frederico Scutti Guard Actor William Howell Aerialist Actor Tom Lazarus Writer Rick Ramage Writer Frank Mancuso Jr. Producer Chris Boardman Original Music Elia Cmiral Original Music Billy Corgan Original Music Mike Garson Original Music Michael Heinkel Original Music Sinéad O'Connor Original Music Jeffrey Kimball Cinematographer Michael J. Duthie Film Editing Michael R. Miller Film Editing Wendy Kurtzman Casting Waldemar Kalinowski Production Design Anthony Stabley Art Director Florence Fellman Set Decoration Louise Frogley Costume Design