Jane Seymour Dr. Michaela "Mike" Quinn Actor Joe Lando Byron Sully Actor John Schneider Daniel Simon Actor Chad Allen Matthew Cooper Actor Shawn Toovey Brian Cooper Actor Jessica Bowman Colleen Cooper Actor Orson Bean Loren Bray Actor Jim Knobeloch Jake Slicker Actor Geoffrey Lower Rev. Timothy Johnson Actor William Shockley Hank Claggerty Actor Henry G. Sanders Robert E. Actor Jonelle Allen Grace Actor Ash Adams Preston A. Lodge III Actor Brandon Douglas Dr. Andrew Cook Actor Barbara Babcock Dorothy Jennings Actor Frank Collison Horace Bing Actor Larry Sellers Cloud Dancing Actor Alex Meneses Teresa Morales Actor Megan Calabrese Guest Star Beth Sullivan Executive Producer Carl Binder Executive Producer, Writer James Keach Director