Roseanne Barr Roseanne Conner Actor John Goodman Dan Conner Actor Laurie Metcalf Jackie Harris Actor Sara Gilbert Darlene Conner Actor Michael Fishman D.J. Conner Actor Johnny Galecki David Guest Star Natalie West Crystal Anderson Conner Guest Star Sandra Bernhard Nancy Bartlett Thomas Guest Star Estelle Parsons Bev Guest Star Matt Roth Fisher Guest Star Danielle Harris Molly Tilden Guest Star Thomas Kopache Donald Bobeck Guest Star Judith Hoag Carrie Guest Star Eileen Heisler Writer DeAnn Heline Writer Andrew Weyman Director